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Shahed Murad’s mission statement as a health researcher

To enable excellence in biomedical research and act as a driving force to accelerate, facilitate, and increase the discovery, development, and dissemination of biomedical innovations that improve health and quality of life.

Shahed Murad has worked as a Biostatistician at the International Centre for Diarrhoeal Disease Research Bangladesh and in the UK at Birkbeck College, Kings College, Imperial College and University College London (UCL).  His main health areas of research are Infectious Diseases and Mental Health.  A highlight of his work is the original and creative analysis of two complex longitudinal data sets and two randomised clinical trials in the fields of cancer, learning disability and depression. His most recent work has culminated in a paper accepted by the Archives of General Psychiatry and one by the American Journal of Psychiatry – the two highest rated journals in Mental Health in the world.

Shahed’s view on Biostatistics in Medical Research

Shahed’s view on missing data mechanism in Medical Research

Shahed Murad’s Publications in Health Research:

  1. Thayyil S, Chandrasekharan S. Taylor A, Bainbridge A,  Cady E, Chong WK, Murad S, Omar RZ, Robertson NJ. Cerebral Magnetic Resonance Biomarkers for Predicting Neurodevelopmental Outcome Following Neonatal Encephalopathy: A Meta-Analysis. Paediatrics . Pediatrics, 2010. 125,  382-395.
  2. Serfaty MA, Haworth D, Blanchard M, Buszewicz M, Murad S, King M. Clinical effectiveness of individual cognitive behavior therapy for depressed older people in primary care: a randomized trial. Archives of General Psychiatry ,2009;66 (12):1332-40.
  3. Hassiotis A, Robotham D, Canagasabey A,  Romeo R, Langridge D, Blizard R, Murad  S, King M. A Randomized, Single-blind, Controlled Trial of a Specialist Behavior Therapy Team for Challenging Behavior in Adults with Intellectual Disabilities. The American Journal of Psychiatry, 2009 (doi:    1176/appi.ajp.2009.08111747).
  4. Omar RZ, Murad S, Edwards SJ Rees G. Biostatistics, its development and dissemination to health researchers Bulletin  of the International Statistical Institute,, 2009
  5. King M, Jones L, Richardson A, Murad S et al. Patients’ experiences of continuity of cancer care and health outcomes: a prospective study,  Brit. J. Cancer 2008 98, 529-536.
  6. Story A, Murad S, Verheyen M, Roberts W, and Hayward AC. Tuberculosis in London- the importance of homelessness, problem drug use and prison. Thorax,  2007; 62: 667-671
  7. Hayward AC, Harling R, Wetten S, Johnson AM, Munro S, Smedley J, Murad S, Watson J. Promoting influenza vaccination for care home staff to prevent death, health service use and morbidity among residents: a cluster randomized controlled trial BMJ. 2006: BMJ 2006; 333: 1241-1244
  8. Aggarwal I, Smith M, Tatt ID , Murad S, Osner N, Geretti AM, Easterbrook PJ. Evidence for onward transmission of HIV-1 non-B  subtype strains in  the UK. JAIDS 2006, 41(2): 201-09)
  9. Mohsen AH, Murad S, and Easterbrook PJ. Prevalence of hepatitis C in an ethnically diverse HIV-1 infected cohort in South London. . HIV Medicine 2005 6; 205-15
  10. Boyd AE, Murad S, O'Shea S, de Ruiter A, Watson C, and Easterbrook PJ. Ethnic differences in stage of presentation of adults newly diagnosed with HIV-1 infection in south London. HIV Medicine 2005 6:2, 59-65
  11. Easterbrook, PJ, A Gibson, S Murad, D Lamprecht, N Ives, A Ferguson, O Lowe, P Mason, A Ndudzo, R Makombe, L Mbengeranwa, C Sola, N Rostogi, F Drobniewski. High rates of clustering of tuberculosis strains in Harare, Zimbabwe: a molecular epidemiological study. Jour. Clin. Mcrobiol 2004; 42(10): 4536 - 4544
  12. Vyakarnam A, Sidebottom D, Murad S, Easterbrook P, Dalgleish AG, Peakman M. Possession of HLA-DQ6 alleles retards the rate of CD4 T-cell decline in HIV-1 infection. Immunology 2004: 112:136-142.
  13. Easterbrook PJ, Waters A, Murad S, Ives N, Taylor C, King D, Vyakarnam A, Thorburn D. Epidemiological risk factors for hypersensitivity reactions to abacavir. HIV Medicine 2003, 4:321-324.
  14. Boaz MJ, Waters A, Murad S, Easterbrook PJ, D’Sousa E, Van Wheeley C,  Vyakarnam A. CD4 responses to conserved HIV-1 T- helper epitopes are discordantly associated with markers of disease progression in HIV-1 chronically infected subjects. Clin. Exp Immunol 2003, 134:454-463.
  15. Omar RZ, Morton LS, Murad S, Taylor KM. Use of flexibility tests in the manufacturing process of 60 degree Bjork-Shiley Convexo-Concave valves and the risk of outlet strut fracture. Journal of thoracic and cardiovascular surgery 2003, 126:832-836.
  16. Mohsen AH, Easterbrook PJ, Taylor C, Portmann B, Kulasegaram R, Murad S, Wiselka M, Norris S. Impact of human immunodeficiency virus (HIV) infection on the progression of liver fibrosis in hepatitis C virus infected patients. Gut 2003;52:1035-1040
  17. Boaz M, Waters A, Murad S, Easterbrook PJ, Vyakarnam A. Presence of gag-specific IFN-IL2 and CD28+IL2+ CD4 T-cell response is associated with non-progression in HIV-1 infection. J Immunol 2002; 169: 6376-6385.
  18. Mazhude C, Jones S, Murad S, Taylor C, Easterbrook PJ. Female sex but not ethnicity is a strong predictor of non-nucleoside reverse transcriptase inhibitor-induced rash. AIDS 2002, Vol 16 No 11.
  19. Morton L, Murad, S, Omar RZ, Taylor K. The importance of emergency identification schemes. Emerg Med J2002;19:584-586.
  20. Davenport ES, Williams CE, Sterne JAC, Murad S, Sivapathasundaram V, Curtis MA.   Maternal periodontal disease and preterm low birth rate: case-control study. Journal of Dental Research 2002;81:313-318
  21. Penny M, Murad S, Lanata CF, Madrid S, Herrera TS, Luczynska C, Piñeiro, A, Caceres D. Respiratory symptoms, asthma, exercise test spirometry, and atopy in school children from a Lima shanty town. Thorax 2001 56: 607-612.
  22. Carroll K, Murad S, Eliahoo J, Majeed A, Stroke incidence and risk factors in a population based prospective cohort study. Health Statistics Quarterly 2001 12, 18-26
  23. Davenport ES, Williams C, Sterne JAC, Murad S, Sivapathasundram V, Curtis MA. Maternal periodontal disease pre-term low birthweight infants. Journal of clinical periodontology 2000 Suppl. Vol 2.
  24. Penny M, Gonzales M, Sterne JA, Smith KR, Lanata C, Murad S, Pineiro A. Nitrogen Dioxide Exposure and Childhood Asthma in a Lima Shanty Town: case-control study. European respiratory Journal, 1999, Vol 14.
  25. Davenport ES, Williams C, Sterne JAC, Murad S, Sivapathasandarum V and Curtis MA. No   association between periodontal disease and low birth weight. Dental Research 1999. 78(5)
  26. Mozumder KA, Koenig MA, Philips JF, Murad S. The sample registration system: an innovative system for monitoring demographic dynamics. Asia Pacific Journal (1990), 5(3) 63–72.

Selected Conference Presentations

Omar RZ, Murad S, Ambler G, Ahmed M and King, M. Use of Multivariate multilevel models to handle missing data in longitudinal studies. Proceedings of the International Society for Clinical Biostatistics, Prague, 2009.

Addiman SJ, Bothamley G, Murad S, Harling R. Route of presentation of TB cases to the TB Service in City and Hackney TPCT 1997–2004, European Respiratory Society Congres, Munich (2006)

Murad S, Hodgson C, Pribram et al. No evidence of body fat redistribution after 2 years treatment with a non-PI based regimen in an anti-retroviral naïve ethnically diverse cohort. XV int. AIDS Conf. Bangkok (2004)

Thevarajan I, Murad S, Mvere m, Goncalves R, Easterbrook PJ. High level of social need among asylum seekers with HIV in south London. BHIVA (2004)

Easterbrook P, Smith M, Mullen J, Oshea S, Geretti AM, Murad S, et al. Relationship between HIV-1 viral subtype, disease progression and response to antiretroviral therapy,   BHIVA (2003) and Retroviruses and Opportunistic Infection, Boston (2003).

Easterbrook P, Smith M, Geretti AM, Osner N, Murad S et al. Impact of HIV-1 viral subtype on disease progression, AIDS Conference, Barcelona (2002)

Easterbrook P, Gibson A, Murad S et al. High rates of clustering of tuberculosis strains in HIV-1 infected patients in Harare. Retroviruses Conference, Seattle (2002)

Aggarwal I, Geretti AM, Smith M, Zuckerman M,  Murad S, Easterbrook P. Epidemiology of  HIV-1 subtype among different ethnic groups in southeast London, BHIVA (2002).

Ambler G, Omar R Z, Murad S, Morton LS, Taylor KM. Risk modelling in heart valve studies, International Society for Clinical Biostatistics (ISCB), Djon.(2002)

Murad S, Omar RZ, Morton LS, Taylor KM. Assessing stability of risk models and their sensitivity to missing data- examples from heart valve studies, ISCB, Stockholm (2001).

Murad S, R.Z. Omar: Issues on estimating the effects of  particulate matter on respiratory diseases from a longitudinal study, Proceedings of the International Society for Clinical Biostatistics, Stockholm (2001).

Murad S. Analysis of left truncated repeated measurement data. Proceedings of the International Society for Clinical Biostatistics, Trento (2000).

Murad S,  Frost C, Hall A. Important issues in the analyses of repeated measurement data from an epidemiological study examining the predictors of anti-HBs in children from the Gambia. Proceedings of the International Society for Clinical Biostatistics, Heidelberg (1999).

Murad S, Islam A. Multistate analysis of diabetes mellitus. Statistical Conference of the Bangladesh Statistical Society, Dhaka, (1988).